In this context, elevated levels of Netrin-1 in HCV+ cirrhotic patients should orient future research efforts not only in the direction of the onset of HCC but also of Netrin’s potential ability to condition the efficacy of direct-acting antivirals (DAAs) through a dysregulated Netrin-EGFR-endogenous interferon sensitive axis. The gene discussed is EGFR; the disease is hepatocellular carcinoma.