Although Netrin-1 expression did not confer a pro-survival advantage to cells used in this study, elevated levels of intrahepatic Netrin-1 may enhance the survival of hepatocytes previously altered and/or rendered more resistant to apoptosis by genetic or tissular injuries, such as HCV trans-acting factors or HCV-related chronic liver regeneration. This evidence concerns the gene NTN1 and digestive system neoplasm.