NTN1 and hepatocellular carcinoma: Netrin-1 mRNA had increased significantly by 25-fold (F0), 15-fold (F1), 17-fold (F2), 12-fold (F3), and 4-fold (F4) in all HCV-infected samples compared to their HCV-uninfected counterparts (HCC: 1.4-fold) (Fig 1G).