Also, detecting these markers in both groups (IHIV-1 pattern group and HCG) below the pathological cut-off levels and the lack of immune activation depending on an antigenic stimulation in these groups (INF-γ induction of neopterin based on Th1 or M/M activation with continous HIV/gp120 stimulation), suggest that this atypical pattern (IHIV-1) may not be an actual HIV-1 infection. The gene discussed is ITIH4; the disease is HIV-1 infection.