Although p16INK4a has been shown to be of prognostic value in a wide variety of cancers and precancerous lesions such as gastrointestinal stromal tumor, non-small lung cancer, osteosarcoma, cervical cancer, and cervical intraepithelial neoplasia, evidence of correlation with vulvar cancer is lacking[12–13,39–41]. This evidence concerns the gene CDKN2A and gastrointestinal stromal tumor.