The present meta-analysis using pooled ORs demonstrated that p16INK4a overexpression correlates significantly with the lower FIGO stage, negative lymph node metastasis, and younger age, consistent with its well-known function of suppressing tumor invasion[47–49].The pooled RR of OS reveals that p16INK4a overexpression indicates a better prognosis for patients diagnosed with vulvar cancer. Here, CDKN2A is linked to neoplasm.