CDKN2A and carcinoma: Although evidence shows improved survival of HPV-induced and p16-positive carcinoma associated with head and neck cancer[50], no detailed studies are found presenting the survival data including both HPV status and p16INK4a.A very few studies presented recurrence rate related to p16 concerning vulvar squamous cell carcinoma (VSCC) after repeated searches for several times, which may be due to the low frequency of VSCC.