Over the past decades, the prognostic value of p16INK4a protein has been evaluated in a wide variety of cancers [9–14].Among these, the study of Hellman et al[15] concluded that p16INK4A expression might be used as a marker for HPV positivity in vaginal carcinoma, which shares a very similar etiology with vulvar cancer. Here, CDKN2A is linked to vulva cancer.