Two our knowledge only two studies, conducted in Italy, have reported the rate of recurrent venous thromboembolism in patients with prothrombin G20210A and cerebral venous thrombosis who discontinue anticoagulation[26,37], none of them showed an increased risk for recurrent venous thromboembolism in carriers of prothrombin G20210A diagnosed with cerebral venous thrombosis. Here, F2 is linked to venous thromboembolism.