KLHDC4 and neoplasm: To further assess the prognostic significance of KLHDC4 in human cancers, we searched the NCBI Gene Expression Omnibus (GEO) repository and found elevated KLHDC4 mRNA levels in tumor samples compared to normal controls in breast (GSE#9574), colorectal (GSE#4107 and GSE#24514), prostate (GSE#6919), pancreatic (GSE#16515) and thyroid (GSE#3678) cancers (Fig 1C).