HP and type 2 diabetes mellitus: Upon evaluation of interaction between IL-1RN and HP polymorphisms in T2DM, it was found that there was no significant interaction between HP 1–2 or 2–2 genotypes with IL-1RN *1/*1 genotype as analyzed by multivariate logistic regression analysis (Odd ratio of interaction variable 0.8064 [95 % CI 0.2569—2.5320, p = 0.7125]) (Table 4) suggesting the association of these two polymorphisms with T2DM risk was independent of each other.