ASB2 is induced by retinoic acid (RA) in acute promyelocytic leukemia cells, and exogenous ASB-2 in myeloid leukemia cells results in growth inhibition and chromatin condensation, which recapitulate the early steps of induced differentiation of acute promyelocytic leukemia cells [106]. This evidence concerns the gene ASB2 and acute promyelocytic leukemia.