The tumor suppressors genes such as EFNA1 (Ephrin-A1), ERRFI1 (ERBB Receptor Feedback Inhibitor 1), LATS2 (Large Tumor Suppressor Kinase 2) and PLK2 (Polo-Like Kinase 2) also show higher average expression in PD0325901 resistant cell lines and thus may be contributing to PD0325901 resistance (Supplementary Table S9). This evidence concerns the gene LATS2 and neoplasm.