Two of these putative transporters contain the MARVEL domain (PF01284): Occludin [SwissProt: Q16625] is a member of the tight junction associated MARVEL proteins (TAMP) [29] and is involved in several diseases including cancer and neurologic disorders; and Synaptophysin [SwissProt: P08247] is involved with structural functions and in targeting vesicles to the plasma membrane [30] and is also involved in cancer, Alzheimer’s disease, schizophrenia, and mental retardation. The gene discussed is OCLN; the disease is early-onset autosomal dominant Alzheimer disease.