KCa3.1 deficiency significantly inhibited diabetes-induced upregulation of LC3 expression in kidney proximal tubules of diabetic KCa3.1−/− mice (K−/− DM) (Fig. 4b), indicating that blockade of KCa3.1 reversed diabetes-induced inhibition of tubular autophagy in diabetic mice kidneys. Here, KCNN4 is linked to diabetes mellitus.