CCND1 and non-small cell lung carcinoma: Our present study also showed that in vitro and in vivo treatment of NSCLC with TC-1 siRNA caused down regulation of the β-catenin target genes c-myc, c-met and cyclinD1. However, the exact mechanisms regulating Wnt/β-catenin and its target genes are complex and a lot of other factors besides Cby that interact with TC-β-catenin to regulate the transcriptional activation (Clevers, 2006; Gordon and Nusse, 2006).