There is a similar result worked on esophageal squamous cell carcinoma which had been published by Lin et al. They had explained that Pin1 positively regulated β-catenin and cyclin D1, and they proved that knockdown Pin1 can inhibit aggressiveness of esophageal squamous cell carcinoma (ESCC) cells [24]. Here, PIN1 is linked to esophageal squamous cell carcinoma.