In Masahiro et al. reports, strong correlation between Pin1 and cyclin D1 immunoexpression and/or cyclin D1 mRNA and Pin1 expression via interaction with Wnt signaling pathway has been observed, and it has been suggested that Pin1 may promote cyclin D1 overexpression directly or through accumulation of beta-catenin in thyroid cancer cells [21]. This evidence concerns the gene CCND1 and thyroid cancer.