REC8 and adrenal cortex carcinoma: There was an additional significant association between ACC in both sexes and a region on chromosome 7 corresponding to a 1.09-Mb segment containing ∼50 protein-coding regions, including RNF212B (a paralogue of RNF212) and REC8 (PLRT = 3.31 × 10−6; Figure 5A and Table S5); this region had not shown any significant associations using the GWAS approach alone.