Abnormal involuntary movements were present in 100% of our cohort of patients with FOXG1 mutations, which supports findings from recent studies that movement disorders are a cardinal feature of this disorder.13,15 Our study clearly demonstrates that FOXG1 syndrome is associated with a wide spectrum of predominantly hyperkinetic movement disorders, most frequently generalized chorea, distal athetosis, dystonia and orolingual/facial dyskinesias. The gene discussed is FOXG1; the disease is Down syndrome.