HNF4A and liver cancer: Using primers specific for ChREBP-α or ChREBP-β and those common for ChREBP-α and ChREBP-β, we found that HNF-4α increased mRNA levels of ChREBP-α, ChREBP-β and total ChREBP in 293T and liver cancer HepG2 cells (Fig. 1d, Supplementary Fig. 1a).