There are reports showing the increase in 5-HT1A receptor binding in the PFC in patients with depression under specified conditions (Matsubara et al., 1991; Arango et al., 1995) and the reduction of 5-HT1A receptor binding after chronic antidepressant treatment in patients with anxiety disorders (Spindelegger et al., 2009). The gene discussed is HTR1A; the disease is major depressive disorder.