Therefore, to determine if the Rho/Rho kinase pathway is modulated by TRPV4-dependent mechanotransduction, we measured Rho activity and found that the absence of TRPV4 significantly increases basal Rho, suggesting that TRPV4 may regulates tumor angiogenesis by maintaining optimal levels of Rho. The gene discussed is TRPV4; the disease is neoplasm.