AKT1 and cancer: The PI3K/Akt pathway is controlled by various antagonistic factors such as the tumor suppressor phosphatase and tensin homolog protein (PTEN) [18–20], glycogen synthase kinase-3β (Gsk3β), a negative modulator in endothelial cells through the Wnt/β-catenin/PI3K/AKT/Gsk3β signaling axis in cancer-induced angiogenesis [21, 22], and the promoter of homeobox gene HB9 [23].