There is substantial evidence to indicate that the zinc-finger transcriptional factors Snail and Slug (the two-handed zinc factors ZEB1/dEF1 and ZEB2/SIP1 and the basic helix-loop-helix transcription factors Twist and E12/E47) play major roles in epithelial carcinoma plasticity [38–41], and tumor progression and invasiveness [42–45]. The gene discussed is ZEB2; the disease is carcinoma.