An insight into the chemoresistance of PANC-1, Mia-PaCa-2 and ASPC-1 pancreatic cancer cells came from a study describing the aggressive and highly metastatic behaviour of pancreatic cancer due to an aberrant expression of nerve growth factor (NGF) and its high-affinity receptor, proto-oncogene TrkA [154]. The gene discussed is NTRK1; the disease is familial pancreatic carcinoma.