For example, it has been reported that only murine integrin expression on tumor vasculature is down-regulated after treatment with low-dosage Abraxane, but that on tumor cells was almost unaffected [33], whereas the ZD4190 may suppress the integrin expression both on the tumor vasculature endothelial cells and tumor cells by primarily targeting vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinase activity [25]. This evidence concerns the gene EGFR and neoplasm.