Interestingly, the expression of integrin αvβ3 on the CNE-2 tumor cell was negligible, and almost all the murine β3 was co-localized with the CD31, all these results demonstrated that the integrin αvβ3 was solely expressed on the tumor vasculature in the CNE-2 tumor tissue. This evidence concerns the gene IGKV4-1 and neoplasm.