IGF1 and Familial prostate cancer: A significantly increased risk for prostate cancer development is due to an augment of circulating IGF-I as shown by Price et al. (2012) [67], others studies also revealed a specifically expression of IGF-I in tumor tissue in prostate cancer suggesting that levels of IGF-I may be a prognostic marker in predicting risk of death in men with advanced prostate cancer [68–70].