Malignant tumor growth is supported also by altered activity of several glycolytic enzymes such as the overexpression of hexokinase [53] and 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase-4 (PFKFB-4) [54] that enhanced the flux through glycolysis. The gene discussed is PFKFB4; the disease is neoplasm.