PBRM1 and neoplasm: In terms of mutations to the commonest ccRCC tumor suppressor genes, baseline mutations (in the untreated samples) were found at the expected frequency, other than for SETD2 which was higher than expected (expected proportion 11%) [10]: VHL mutation in 6 of the 12 patients for whom germline DNA was available (50%; Supplementary Table 5), PBRM1 in 4 patients (33.3%), BAP1 in 3 patients (16.7%) and SETD2 in 6 patients (41.7%).