However, when looking at other tumors (profiled using the more recent HM450 version of the array, e.g. in colon adenocarcinoma dataset, COAD, HM450 data for a subset of the tumors), 3 probes targeting the VHL region of described in our work (i.e. cg10352003, cg06034437 and cg01998262), exhibit clear methylation. The gene discussed is VHL; the disease is colon adenocarcinoma.