CDKN2A and cervical intraepithelial neoplasia: The overexpression of p16 in cervical dysplasia was reported to be associated with the transforming activity of the E7 oncoprotein of HR-HPV types through inactivation of the tumor-suppressor function of the retinoblastoma protein (pRb) [18], which may lead to malignant transformation when it occurs in DNA replication-competent cells.