Many studies have been conducted to assess the clinical utility of p16/Ki-67 dual-staining for the detection of HG CIN in primary cervical screening or in ASCUS/LISL triage as well as for the triage of Pap cytology-negative, HPV positive screening results [13-15], but no such data were available in China. The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.