CXCR2 and ovarian carcinoma: CXCR2 has been shown to be overexpressed in ovarian cancer cell lines and to promote cancer metastasis [13] and so its role in anaesthetic-mediated effects on tumour biology was investigated: after transfection with CXCR2 siRNA, the post-exposure expression of CXCR, was all reduced significantly (Figure 3A and 3B).