ARHGEF3 and nasopharyngeal carcinoma: We analyzed endogenous ARHGEF3 protein levels in 8 human nasopharyngeal cell lines by Western blotting and found that ARHGEF3 was overexpressed in 5 NPC cell lines (CNE2, SUNE1, 5-8F, 6-10B and C666), while the other 2 NPC lines (CNE1 and HONE1) and the immortalized normal nasopharyngeal cell line NP69 exhibited low ARHGEF3 protein levels (Figure 1A, left).