To further study the effect of ARHGEF3 on NPC cell apoptosis, we transfected CNE2 and SUNE1 cells with either siARHGEF3 or siBIRC8 for 48h and found that knockdown of ARHGEF3 and BIRC8 increased apoptosis in both CNE2 and SUNE1 cells compared with control cells. Here, ARHGEF3 is linked to nasopharyngeal carcinoma.