ARHGEF3 and nasopharyngeal carcinoma: To investigate if abnormalities in ARHGEF3 are involved in NPC pathogenesis, we examined ARHGEF3 protein levels in a series of carcinomatous and non-neoplastic human nasopharyngeal cells and tissues, assessed the clinicopathologic/prognostic significance of ARHGEF3 expression in our NPC cohort, and investigated the mechanisms underlying the oncogenic and tumorigenic role of ARHGEF3 in NPC.