More recently, altered MDS-like phenotypes involving maturing and mature neutrophils, monocytic and/or erythroid precursors, have also been found in adult patients with mature lymphoid malignancies such as multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS) cases; of note, these patients frequently showed also MDS-related genetic changes in the phenotypically altered BM myeloid cells and CD34+ precursors [16]. The gene discussed is CD34; the disease is myelodysplastic syndrome.