Altogether, these observations suggest that the course of BCP-ALL more likely depends on features of the disease related to the tumor cells, tumor burden and response to therapy, than to the presence of an underlying altered hematopoiesis, at least in the short-to-medium term, which is also supported by the progressive recovery of CD10 expression on neutrophils from treated BCP-ALL cases here reported. The gene discussed is MME; the disease is acute lymphoblastic leukemia.