AKR1B1 and breast carcinoma: Subsequently we validated a new set of genes in sporadic breast cancer tissue and demonstrated that the promoters of the AKR1B1, ALX1, GHSR, GREM1, RASGRF2, SFRP2, TM6SF1 and TMEFF2 genes were significantly differentially methylated in normal versus malignant breast tissues [10-12].