Moreover, we used the MRI and histology examination to determine whether the MKK7 p.Glu116Lys could cause tumor metastases, and found that all the mice injected with A549 cells over-expressing MKK7-116Lys suffered from pulmonary metastasis, while the mice group injected with MKK7-116Glu A549 cells did not (Fig 3C, 3D and 3E). The gene discussed is MAP2K7; the disease is neoplasm.