The GO results indicated that these 192 differentially expression genes were annotated to be associated with cell cycle process, cell proliferation, apoptosis, tissue development, tumor invasion, and metastasis et al. Above results suggests that alteration from 116Glu to Lys in MKK7 might influence its downstream targets expression and thus facilitate lung cancer initiation and development. This evidence concerns the gene MAP2K7 and lung carcinoma.