Based on three independent case-control studies, we have obtained consistent results of the association between the MKK7 p.Glu116Lys rare variant and lung cancer risk and prognosis, with a compellingly strong study power of 100% (two-sided test, α = 0.05) to detect an OR of 3.29 for the 116Lys variant genotypes (which occurred at a frequency of 2.7% in the controls), and with a 100% statistical power for HR with a value to 1.53, while compared with the 116Glu wild-genotype. The gene discussed is MAP2K7; the disease is lung cancer.