In the current study conducted among southern and eastern Chinese with a total of 5,016 lung cancer patients and 5,181 controls, we estimated the relationships between rare variants in MKK7 gene and lung cancer risk and prognosis, and found that the p.Glu116Lys rare variant was significantly associated with an increased lung cancer risk, progression and prognosis. This evidence concerns the gene MAP2K7 and lung carcinoma.