CACNA2D3 and autism: [70] The startle reflex modulation, as measured by prepulse inhibition, is a putative endophenotypes of schizophrenia.[71] In an exome sequencing study of autism, a single subject suffering from autism also had a mutation in CACNA2D3.[72] Given the evidence for members of the calcium pathway in schizophrenia, this variant could be of interest for further research.