The WISP3 gene lies within the 6q21 region, within a larger region on chromosome 6 previously associated with schizophrenia or bipolar disorder.[50–54] Although neither WISP3 nor the neighbouring TUBE1 or LAMA4 genes, have been associated with schizophrenia, the more distant FYN gene was.[55]. Here, TUBE1 is linked to bipolar disorder.