Animal models have not highlighted further evidence for WISP3 as a schizophrenia candidate gene: Although WISP3 is expressed in the developing midbrain of zebrafish,[57] altering the expression of WISP3 does not affect the phenotype of mice.[58] No association of WISP3 with schizophrenia has so far been described in the current literature. This evidence concerns the gene CCN6 and schizophrenia.