APC and breast carcinoma: A large number of well-established cancer genes have been implicated in breast cancer development, including BRCAl, RB1, TP53, PTEN, AKT1, CDH1, GATA3, and PIK3CA. Other groups of genes responsible for signal transduction including APC, ARID1A, ARID2, ASXL1, BAP1, KRAS, MAP2K4, MLL2, MLL3, NF1, SETD2, SF3B1, SMAD4, and STK11, have also been found to contain somatic mutations in tumors.