In addition, to further evaluate the possible association between IL18 and progression of cardiomyopathy, we compared IL18 allelic and genotypic frequencies by grouping asymptomatic + CII individuals and CIII + CIV individuals; however, similar to that observed in the previous analysis, no statistically significant differences were yielded (Table C in S1 Text). This evidence concerns the gene IL18 and cardiomyopathy.