In addition, C188-9 was effective at reducing levels of constitutively activated STAT1 in UM-SCC-17B cells (IC50=19.1 μM, Table 2) as well as SCC61 and HN30 (IC50=28.5 and 5 μM respectively, Table 2) but not in SCC-35, which did not have significantly higher pSTAT1 levels compared to the non-tumor line HEEpiC (Table 2, Supplementary Figure S1B. The gene discussed is STAT1; the disease is neoplasm.