In addition to promoting many hallmarks and enablers of cancer, STAT3 activation has been linked to resistance to radiation therapy in cells obtained from several normal tissues and cancers, including HNSCC [19], through several mechanisms, including EGFR signaling [44], HER2-STAT3 cross-talk [45], and activation of the LIF-STAT3 axis [46]. Here, EGFR is linked to cancer.