In univariate Cox proportion hazard ratio analysis, age, tumor(T) stage, Node(N) stage, metastasis(M) stage, FOXD3, FOXO4 and FOXS1 expression were significantly associated with prognosis in terms of OS of patients with gastric cancer in the TCGA cohorts (p < 0.05, Table 2). The gene discussed is FOXD3; the disease is gastric cancer.