We used Kaplan-Meier methodology to examine the impact of PLR on OS in patients stratified by age, BMI, tumor differentiation, gender, tumor stage and CEA, PLR quintiles were significantly associated with poor survival in older (> 65 years) (Figure 2B) male (Figure 3A) patients with advanced tumor TNM stage (III and IV) (Figure 4B), normal range of CEA (≤ 5ng/ml) (Figure 5A) and BMI (≤ 25) (Figure 6A) (P < 0.01 for all measurements). This evidence concerns the gene CEACAM5 and neoplasm.