TAC1 and neoplasm: Moreover, based on a multivariate Cox proportional hazard regression of 59 patients with N0 lymph-node status, which included age, gender, smoking status, and tumor stage, the group with methylation of E-cadherin, COL1A2, TAC1, and GALR1 had a 4.474-times greater hazard than the group without methylation (Table 3).