In the present study, we found that HG or hyperglycemia could increase the expression and activity of PARP-1 and induce inflammatory response, while PARP-1 inhibition significantly reduced the inflammatory response, including the secretion of TNF-α, IL-1β and IL-6 and the expression of ICAM-1 and iNOS. The gene discussed is NOS2; the disease is Hyperglycemia.