Moreover, as shown in Figure 8F to 8H, hyperglycemia reduced p-IGF-1R and p-Akt expression, while PARP-1 deletion could increase their expression, which suggested that PARP-1 deletion protected cardiomyocytes from apoptosis partly through activation of IGF-1R/Akt pathway. This evidence concerns the gene AKT1 and Hyperglycemia.