In good accordance, not only the protein level of the transcription factor is influenced by CDK5 inhibition, but also the transcription of its target genes VEGFA and EphrinA1. VEGFA and EphrinA1 are both important modulators of angiogenic processes [11, 27] and EphrinA1 has been shown to be highly upregulated in HCC, promoting cell growth of hepatocellular tumors [27]. Here, VEGFA is linked to hepatocellular carcinoma.