In addition to GAS5, HNF1A-AS1 was up-regulated in esophageal adenocarcinoma and that it could induce the expression level of lncRNA H19 and lead to an increase in cell proliferation, migration and invasion, Nevertheless, we discovered another underlying molecular mechanism of HNF1A-AS1 which plays a key role in lung adenocarcinoma tumorigenesis. The gene discussed is HNF1A; the disease is esophageal adenocarcinoma.