GSK3B and breast carcinoma: It can inhibit the proliferation of MCF-7 and MDA-MB-231 human breast cancer cells and PC3 human prostate carcinoma cells via G1-phase arrest [125, 126] and induce apoptosis in breast cancer cells via the mitochondrial apoptotic pathway and Akt/GSK-3beta/cyclin D1 signaling [127, 128].