Tetrandrine also exhibited a synergistic caspase-dependent apoptotic cell death effect in combination with chloroquine, which was widely clinically utilized to treat malaria and other diseases [101], in human hepatoma cell lines (Huh7 and FHCC98), human glioma cell lines (U87 and U251), human lung cancer cell lines (Calu-1 and A549), and human cervical adenocarcinoma HeLa cells via ROS production and p21CIP1/WAF1 expression [75]. This evidence concerns the gene CDKN1A and central nervous system cancer.