TGFB1 and neoplasm: Tumor microenvironment comprising surrounding fibroblasts, endothelial cells, and tumor-associated macrophages, contributes to the EMT through the production of TGF-β and FGF, together with exhibition of tumor heterogeneity and formation of cancer stem cell niches associated with therapeutic resistance against irradiation, chemotherapy, and molecular-targeted reagents [12–14].