The preferential preoperative parameters for poorer survival rate in patients undergoing liver surgery included: (1) age over 57; (2) BMI < 25; (3) gender (male); (4) abnormal serum AST level; (5) hypoalbuminemia (serum albumin level < 3.5mg/dL); (6) hyperbilirubinemia (serum bilirubin > 1.2mg/dL) (7) higher serum AFP (AFP > 400mg/dl); (8) higher Child-Pugh grading (with a Child-Pugh grade of B or C); (9) poorly differentiation; (10) higher TNM stage grading; (11) greater tumor size ( > 5 cm); (12) the detection of vascular invasion and (13) multiple tumors. The gene discussed is ALB; the disease is Hyperbilirubinemia.