Next, we assessed whether all these alterations in the immune response: robust increase in GITR expression in several cells from the immune system, together with the increase in IFN-γ, TNF-α, and IL-6 production and a decreased IL-10/ IFN-γ at sites of parasite replication in the acute stage of infection, would lead to an increased parasite killing in the chronic stage of the disease. This evidence concerns the gene IL6 and infection.