Sensitivity and specificity are 82.1% and 3.7%, respectively, for TpP >5.4 ug/mL, indicating that increased D-dimer and TpP levels in HCC are associated with fibrinolysis and coagulation during PVTT and that a positive TpP level is a predictor of tumor thrombosis in HCC. This evidence concerns the gene TNS3 and hepatocellular carcinoma.