Besides, on the basis of the documented correlation of eGFR to CRP in patients with CKD (Tong et al. 2007; Dubin et al. 2011), increased hs-CRP levels in our ADPKD patients with preserved renal function seems to indicate the likelihood of both CRP mediated inflammatory changes to occur at much earlier stages of renal disease. The gene discussed is CRP; the disease is kidney disorder.