REN and endothelial dysfunction: This finding is supported by several other studies, and development of LVH in normotensive ADPKD patients may have caused by several reasons including; renin-angiotensin-aldosterone system activation, adrenergic stimulation, endothelial dysfunction and diastolic dysfunction (Ecder and Schrier 2009; Martinez-Vea et al. 2000; Kocyigit et al. 2014; Pietrzak-Nowacka et al. 2012; Chapman et al. 1997).