Although many studies have focused on 5-HIAA, CRP, procalcitonin, interleukins, leptin and NUCB2/nesfatin-1, lipopolysaccharide binding protein, etc., appendicitis is still difficult to diagnose at an early stage with such laboratory tests (Rodriguez-Sanjuan et al. 1999; Apak et al. 2005; Mentesa et al. 2009; Brănescu et al. 2012; Bakal et al. 2015). This evidence concerns the gene NUCB2 and appendicitis.