Literature data indicated that PLC ε is important for heart development (Tadano et al. 2005; Wang et al. 2005), is involved in nephrotic syndrome (Hinkes et al. 2006), increases insulin secretion (Dzhura et al. 2011), and is highly expressed in the lung (Smrcka et al. 2012). The gene discussed is INS; the disease is nephrotic syndrome.