In this case-control study, we investigated the potential associations between polymorphisms in TNF (-238G>A (rs361525)), IL1B (-511C>T (rs16944)), IL1B (-31T>C (rs1143627)), ACVRL1 (IVS3-35A>G (rs2071219)), ENG (207G>A (rs11545664)), IL6 (-174G>C (rs1800795)), and APOE with the risks of developing BAVM and ICH. The gene discussed is IL6; the disease is arteriovenous malformations of the brain.