PTEN and prostate carcinoma: Since mTORC2 and pAKT-S473 are necessary for PTEN deletion-induced tissue overgrowth in drosophila eyes (Hietakangas and Cohen, 2007) and development of prostate cancer in mouse (Guertin et al., 2009), targeting/blocking mTORC2 may allow us to boost PTEN/AKT’s regeneration-promoting effect while at the same time minimizing its deleterious tumorigenic effect.