SORL1 and Alzheimer disease: We analyzed the coding sequence of SORL1 in 1255 European early-onset AD patients and 1938 origin-matched control individuals and identified 92 rare frameshift, nonsense and nonsynonymous variants (MAF < 0.01) in a total of 219 individuals, of whom 111 (51 %) were patients (Fig. 1; Supplementary tables 2, 3, 4).