EIF4EBP1 and renal cell carcinoma: Furthermore, p-4EBP1 has recently been reported to correlate with aggressive pathologic grade and inferior prognosis regardless of the upstream oncogenic alterations in a great deal of malignancies including RCC, endometrial carcinoma, breast cancer, ovarian cancer, melanoma, cervical carcinoma, astrocytoma, esophageal squamous cell carcinoma and hilar cholangiocarcinoma13, 14, 16, 17, 18, 19, 20, 21, 22, 23.