Specifically, levels of polyunsaturated fatty acids (PUFAs) such as AA and the marine omega‐3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may modify the relation of ALOX5 and CHD outcomes as suggested by previous studies.11, 12 Finally, race/ethnicity remains an important consideration in genetic studies, but whether it may uncover or otherwise modify putative associations of ALOX5 gene variants and atherosclerosis or CHD outcomes has yet to be examined. This evidence concerns the gene ALOX5 and atherosclerosis.