SP1 and atherosclerosis: In a cohort of 470 healthy, middle‐aged individuals from the Los Angeles Atherosclerosis Study, participants with 2 copies of variant alleles (deletion or insertion of Sp1 motifs) of a tandem SP1 binding motif polymorphism in the ALOX5 promoter region showed an increase in cIMT compared with those who carried the wild‐type allele.8 This association was enhanced by dietary intake of AA and blunted by intake of long‐chain omega‐3 fatty acids EPA (20:5, n‐3) and DHA (22:6, n‐3).