While previous studies using cell culture, animal models, and human case‐control designs have supported a role for LOX‐5 pathways in the development of atherosclerosis, we found that ALOX5 SNPs were not associated with either the presence of atherosclerosis or CHD incidence over time—even after considering interactions with plasma fatty acids and race/ethnicity. The gene discussed is ALOX5; the disease is coronary artery disorder.